Two postdoctoral positions are available to study corticospinal system development, organization, and repair in mice and rats. A major overall focus of the lab’s research program is on devising genetic and activity-based approaches for strengthening corticospinal tract connections spared after an incomplete spinal injury. The laboratory website provides additional information (http://martinlab.ccny.cuny.edu/).
The present positions, which are funded through grants from the NIH (2R01NS064004) and the Craig H Nielsen Foundation, are for postdoctoral scientists with experience working with rodents. We use electrophysiological (spinal cord recording, motor cortex motor mapping) and anatomical (including tract tracing, immunohistochemistry, in situ hybridization, and confocal microscopy) methods to study development and repair in animals. We use behavioral (reaching, locomotion, reflex testing) techniques for evaluating functional outcomes. The successful candidate should have experience in one or more of the experimental techniques listed above and will be trained in the other methods. It is particularly important to have experience conducting animal surgeries, perform in vivo procedures, and especially for the mouse work, an understanding of genetic approaches.
Recent animal models and related research questions are detailed in the following publications of the lab: Science 357: 400–404 (2017); J Neuroscience 34:5211–5221 (2014); J Neuroscience 38 :8329–8344 (2018).
Email CV and the names and contact information of three references to John H. Martin, Ph.D. (email@example.com).
PHD, MD, or equivalent
Experience with animal surgery
Experience with one or more of the following: optogenetic activation; DREADD-based activation and inactivation; anatomical techniques (tract tracing, viral tracing, immunohistochemistry, microscopy; behavioral testing; electrophysiology (systems, cellular); aseptic surgery and working with chronic animal preparations; genetic manipulations to dissect anatomical, physiological, and behavioral outcomes.
Internal Number: PD2019
About City University of NY School of Medicine
The Martin laboratory studies how the nervous system controls limb movement, such as walking and reaching, from the dual perspectives of brain development and recovery of motor function after brain or spinal cord injury. Our studies focus on the corticospinal motor system and on the spinal motor circuits that are the targets of the corticospinal system. We are interested in elucidating the mechanisms by which the specificity of these connections are established during development and in devising ways to reestablish this specificity after injury. We use a diversity of animal models to study the question of corticospinal system development and repair. An important focus of the lab is to translate what we learn in the animal into therapies for humans with mobility impairments. Research in the lab is supported by grants from the NIH, NYS Department of Health, and private foundations.
The laboratory, which is part of the City University of New York School of Medicine, is located at the City College of NY South Campus in northern Manhattan, in the Center for Discovery and Innovation. The South Campus is also where the CUNY Advanced Science Research Center is located. The CCNY Center for... Discovery and Innovation and the CUNY Advanced Science Research Center together comprise CUNY’s newest premier science research facility. Please see the laboratory website for updates : http://martinlab.ccny.cuny.edu/